Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing. Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response Unfolded protein response. UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기
Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart TissuesArticle Published on 2022-10-012022-11-15 Journal: Advanced Science [Category] 신약개발, 치료제, [키워드] antiviral drugs approved drugs ATP2A2 cardiotoxic effect Cardiotoxicity cell death Clinical data clinical trial clinically concentrations contractile Coronavirus disease 2019 COVID-19 demonstrated drug drug candidate drug treatments dysregulation effective engineered heart tissue evaluate expression of gene fumarate handling HCN4 heart heart tissue High Throughput Screening Human human pluripotent stem cell-derived cardiomyocytes induced ion homeostasis limit MYH6 Patient powerful tool regulate Remdesivir Repurposed drug repurposed drugs for COVID-19. reveal Ritonavir RNA-seq analysis significantly Spread STEM therapy TNNT2 [DOI] 10.1002/advs.202203388 PMC 바로가기
Induction of Hypoxic Response in Caco-2 Cells Promote the Expression of Genes Involved in SARS-CoV-2 Endocytosis and TranscytosisArticle Published on 2022-10-012022-11-16 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 analyzed Caco-2 Caco-2 cell downregulation elevated endocytosis expression expression level expression of gene hypoxia hypoxic include increase in induction intestine involved LDL LDLR low-density LRP1 LRP4 LRP5 manuscript mechanism miRNA mRNA oxyquinoline receptor response RNA sequencing SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 viral particles significant increase TFRC Transcriptome Transcriptome. transcytosis Transport treated upregulation [DOI] 10.1134/S1607672922050118 PMC 바로가기
Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infectionArticle Published on 2022-09-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Activation Affect Antiviral Biomarker blood cell change changes in Cohort coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNA DNA methylation effector Epigenetic epigenetics expression expression of gene Hospitalized identify Infection intensive care unit Interaction interferon response involved lesion management Methylation MOST outcomes pathology pathophysiology pathway Patient populations Potential treatment recent reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Severity of infection shown subset Symptom Symptoms the disease transcriptomics upper respiratory tract [DOI] 10.1016/j.biopha.2022.113396 PMC 바로가기
Antimicrobial Activity of the Serum before and after Vaccination with EpiVacCoronaEpiVacCorona 백신 접종 전과 후 혈청의 항균 활성Article Published on 2022-07-012022-09-12 Journal: Bulletin of experimental biology and medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activity antimicrobial antimicrobial activity antimicrobial peptide antimicrobial peptides Cell coronavirus correlated demonstrated EpiVacCorona evaluated expression expression of gene fraction initial inverse correlation Normal distribution PCR peptides reverse transcription SARS-CoV-2 antigen sera serum specific IgG antibodies specific IgG antibody Total vaccination vaccination. Vaccine Volunteer was measured [DOI] 10.1007/s10517-022-05548-6 PMC 바로가기 [Article Type] Article
Fibronectin as a Marker of Disease Severity in Critically Ill COVID-19 Patients중환자 COVID-19 환자의 질병 중증도 지표로서의 피브로넥틴Article Published on 2022-05-062022-09-11 Journal: Cells [Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] Alter APACHE II Bacterial Bacterial sepsis Biomarker Biomarkers can be used cellular clinical setting clinical settings correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples Critically ill Critically ill patient critically ill patients disease severity ELISA etiology expression of gene Extracellular matrix Fibronectin form help Ill immune response immunoblotting Infection Intensive intensive care intensive care unit knowledge MONITOR Mortality mortality prediction. no significant difference no significant differences Non-survivors outcomes Patient plasma predict Proteins proteolytic Research SARS-CoV-2 virus Sepsis significantly higher SOFA scores treated Treatment Treatment outcome Viral was related were measured [DOI] 10.3390/cells11091566 PMC 바로가기 [Article Type] Article
Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung OrganoidshiPSC에서 파생된 폐 오르가노이드에서 SARS-CoV-2에 대한 두 가지 다른 치료 접근 방식Article Published on 2022-04-052022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] ACE2 airways alveolar approach approaches AT2 candidate Cell complex COVID-19 COVID-19 treatment develop dipeptidyl peptidase Dipeptidyl peptidase-4 distal DPP4 drugs Efficacy Efficiency evaluate Evidence Express expression of gene health emergency hiPSCs hLORGs homologous host cells human cells implicated in vitro in vivo Infection Inflammatory response Innate immunity lung modulation monoclonal Neutralizing neutralizing antibody neutralizing monoclonal antibody organ Organoid peptide pluripotent stem cell Protein proximal pseudovirus receptor receptors reducing reduction SARS-CoV-2 SARS-CoV-2 S SARS-CoV2 SARS-CoV2 pseudovirus spike Spike protein stem cells Structure synthetic peptide. tested tetravalent therapeutic These data treated Treatment variant Viral viral entry were infected [DOI] 10.3390/cells11071235 PMC 바로가기 [Article Type] Article
Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory DiseasesReview Published on 2022-03-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] advance Agonism agonist antioxidant application Autoimmune diseases Cell cell damage cellular clinical Clinical practice clinical trials complications Coordinate diabete Diabetic disease disorders dysfunction Enzymes Evidence expression of gene fat homeostasis implication Inflammation Inflammatory bowel disease inflammatory disease metabolic metabolic disease molecular Nrf2 obesity organism oxidative stress Pathogenesis pathway Potential Protein recent regulated Regulation Stress therapeutic use tissue transcription factor understanding [DOI] 10.3390/ijms23052846 PMC 바로가기 [Article Type] Review